Celebrating LSU’s Culture of Innovation

Fifteen new patents to be featured April 25

BATON ROUGE – Inventions that will improve cancer treatment, prolong cell phone battery life and even eliminate a disease in horses are among the 15 new LSU patents that will be recognized at the Inventorship Showcase on April 25.

“Obtaining a patent is no small feat. It requires a significant amount of time, effort and determination to bring an idea to fruition. We will spotlight and celebrate these faculty inventors whose perseverance, amidst their teaching, research and administrative responsibilities, have resulted in patents with the potential to improve people’s lives,” said Andrew Maas, director of the LSU Office of Innovation & Technology Commercialization, which organizes the Inventorship Showcase.

At the event, the Excellence in Innovation award will be given to the E. J. Ourso College of Business for its efforts in creating the Stephenson Department of Entrepreneurship & Information Systems, which launched a new bachelor’s degree in entrepreneurship this academic year. Recognizing that all LSU students can benefit from an entrepreneurship program, it is open to students pursuing a concurrent degree in any college on the LSU campus. The 12 currently enrolled entrepreneurship students are combining their entrepreneurship degree with engineering, Spanish, music, business and textiles, apparel and merchandising.

“My job as dean is to focus on the future – not mine but the 1,100 students we graduate each year. Our new entrepreneurship degree is an important step in helping our graduates create new businesses, launch exciting careers and contribute to the economic development of the region,” said E. J. Ourso College Dean Richard White Jr.

The fourth annual Inventorship Showcase will be held in the Lod Cook Alumni Center from 5:30 to 7:30 p.m., and is open to the public.

Patents issued to LSU inventors between July 1, 2016, and June 30, 2017 that will be featured include:

(Please note: LSU affiliated employees and students at the time of invention are indicated in bold.)

Self-healing Composite of Thermoset Polymer and Programmed Super Contraction Fibers
US 9,428,647
Issue Date: Aug. 30, 2016
Guoqiang Li and Harper Meng
This patent protects a novel polymer that uses the two-step “close then heal” process for macrocracks. This polymer contains fibers that are programmed into a temporary shape which is then embedded into a conventional polymer matrix. When a macroscopic crack is created in the polymer matrix, the crack is healed by heating the material. The fibers shrink and close the crack. Further heating melts the fibers and the molten thermoplastic molecules are sucked in the narrowed crack by capillary force and diffused into the fractured SMP. When cooled down, the material hardens, thus healing the crack at the molecular level. The invention can be used in any lightweight structure such as aircraft, ships, cars, trains, piping, pressure vessels and non-load bearing electronic devices such as computers and cell phones.

Energy Efficient Job Scheduling in Heterogeneous Chip Multiprocessors Based on Dynamic Program Behavior Using PRIM Model
US 9,436,512
Issue Date: Sept. 6, 2016
Lu Peng and Bin Li
This patent protects a new computer chip configuration that is optimal at efficiently scheduling multiprocessor time through hardware interfaces. The program scheduler, which is responsible for program-to-core assignments during runtime, is aware of differences between integrated processors and program behaviors and makes optimal job assignments to a given core during runtime. In short, this invention will help improve the battery life of cell phones.

Fatigue Monitoring for Composite Materials
US 9,476,815
Issue Date: Oct. 25, 2016
Michael Khonsari and Mehdi Naderi Abadi
This patent protects a new method to monitor, analyze and predict when a material will fail under cyclic loading. Specifically, through this methodology, the failure in a material can be anticipated solely on a temperature reading of the material while being loaded. The benefit of the method is that it does not require full load history to be able to anticipate fatigue failure. The anticipated fatigue failure can be achieved with a short history of the temperature of the material in service. This technology has applications in machinery, pumps and turbines.

Inhibitors of PFKFB3 for Cancer Therapy
US 9,492,418
Issue Date: Nov. 15, 2016
Yong-Hwan Lee and Jeong Do Kim
This patent protects a new analytical tool for small molecules, inhibitors of the enzyme PFKFB3. These inhibitors were tested in cervical and breast cancer cell lines leading to massive cell death. PFKFB3 plays an important role in glycolysis – the metabolic pathway in eukaryotes which has been found to be overexpressed in multiple types of cancer including: thyroid, breast, colon, prostatic and ovarian tumor cell lines. The unique feature of this invention is that it can be applied broadly to many types of cancers.

Thermosetting Shape Memory Polymers with Ability to Perform Repeated Molecular Scale Healing
US 9,493,643
Issue Date: Nov. 15, 2016
Guoqiang Li
This patent protects a novel polymer and the methods to make the polymer which can mimic the biological healing process of human skin by first closing the wound followed by a healing step. This approach, termed the “close then heal” process, uses a shape memory polymer for purposes of narrowing or closing a microscopic crack and then molten thermoplastic particles are used for healing at the molecular scale. The unique feature of the invention is that it enables a material to close macroscopic defects multiple times even if another wound occurs in a previously healed area. The invention can be used for protecting civilian structures, law enforcement and military equipment and to help seal cracks in any structure such as aircraft, ships, cars, trains, asphalt and concrete.

Apparatus and Method for Nanocomposite Sensors
US 9,518,878
Issue Date: Dec. 13, 2016
Jin-Woo Choi and Chao-Xuan Liu
This patent protects an ultra-sensitive pressure sensor made from patterned conductive nanomaterials. The use of conductive nanomaterials embedded within a flexible polymer allows for precise electrical measurements to be made as the composite layer deforms due to pressure. The sensor is useful to a variety of industries in any application where pressure needs to be measured or monitored.

Method for DNA Double-strand Break Repair in Vitro and Applications Thereof
US 9,546,396
Issue Date: Jan. 17, 2017
John Battista, Michael Cox, Audrey Klingele and Joseph Piechura
This patent protects a system to repair DNA double-strand breaks efficiently and in vitro. This technology permits damaged or poor quality DNA samples to be used in forensic testing, DNA extraction from ancient sources, genome sequencing and metagenomics.

Peptide for Protection of Allergic Respiratory Disorders
US 9,546,200
Issue Date: Jan. 17, 2017
Changaram Venugopal and Sudhirdas K. Prayaga
This patent covers a small peptide that can be used to treat Recurrent Airway Obstruction, or RAO, in affected horses. RAO a debilitating disease very similar to human asthma and is one of the most commonly diagnosed conditions affecting as much as 15 percent of the worldwide horse population. This is the first ever vaccine for the elimination of the disease rather than just addressing symptom relief.

Mechanical Seal with Textured Sidewall
US 9,568,106 
Issue Date: Feb. 14, 2017
Michael Khonsari and Nian Xiao
This patent protects a rotating mechanical seal that uses specialty patterned dimpled surface treatments on the interfacing surfaces to create strong seals around the two surfaces. These specialty surfaces have several advantages. The main one being that the operating temperature is held lower due to minimal friction, which allows for longer operating life. This invention is superior to other mating rings due to the improved heat transfer away from the sealed surface and improved wear characteristics without loss of sealing pressure. This technology has applications in rotating machinery, pumps and turbines.

Nanoparticles, Nanosponges, Methods of Synthesis and Methods of Use
US 9,574,136 
Issue Date: Feb. 21, 2017
Kun Lian
This patent covers methods of making metallic nanoparticles coated with a thin protective carbon shell. The nanoparticles have antimicrobial and antibacterial properties, and can also be used for wood preservation. Other applications include strengthening of polymer and fiber/polymer materials and catalysis. A LSU I-Corps student team is interested in licensing the patent for the development of antimicrobial and anti-odor athletic wear and other textiles.

Method of CO and/or CO2 Hydrogenation Using Doped Mixed-Metal Oxides
US 9,598,644 
Issue Date: March 21, 2017
James J. Spivey, Dushyant Shekhawat, David A. Berry, Daniel J. Haynes, Victor Abdelsayed and Mark W. Smith
This patent protects a new hydrogenation method that synthesizes higher alcohol/oxygenates from syngas. Syngas, or synthesis gas, is a fuel gas mixture produced from coal, natural gas and biomass that can be used for a variety of applications including liquid transportation fuels and chemical intermediaries. The method relies on a new pyrochlore-based catalyst with the added advantages of high selectivity towards higher alcohols, higher activity toward syngas conversion at relatively lower temperatures and pressures and high stability in the presence of a reducing environment without the need for multiple catalysts.

Cooled Seal
US 9,599,228
Issue Date: March 21, 2017
Michael Khonsari and Nian Xiao
This patent protects a primary rotating sealing ring that aligns with a mating stationary ring, which incorporates a heat transfer mechanism that is integrated to the mating ring. This mechanism allows for cooler operating temperatures on these seals which extends the useful life of the machinery. This technology has applications in rotating machinery, pumps and turbines.

Controlled Radical Polymerization and Catalysts Useful Therein
US 9,644,072  
Issue Date: May 9, 2017
Evgueni Nesterov, Jinwoo Choi and Carlos Chavez
This patent protects catalysts that are suitable for convenient, cost effective means for the controlled preparation of high molecular weight polythiophenes, other semiconducting polymers, as well as corresponding block copolymers. Polythiophenes have applications in field-effect transistors, electroluminescent devices, solar cells, batteries, diodes and chemical sensors.

Carcinoma Homing Peptide (CHP), Its Analogs and Methods of Using
US 9,657,077 
Issue Date: May 23, 2017
Jeffry John Cutrera, Xueqing Xia and Shulin Li
This patent covers tumor targeting peptides, named carcinoma homing peptides, that deliver therapeutic cancer compounds directly to tumorous environments by targeting vimentin, a receptor protein that is overly expressed on the surface of tumor cells. Several companies have demonstrated interest in the patent.

Methods and Devices for DNA Sequencing and Molecular Diagnostics
US 9,670,540 
Issue Date: June 6, 2017
Steven Soper, Daniel Sang-won Park, Michael Murphy, Robin Lindsey McCarley, Francis Barany, George Grills, Yu-wei Cheng, Jianmin Huang, Hong Wang, Malgorzata Witek and Mateusz Hupert
This patent protects methods and devices for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The invention is designed to standardize molecular diagnostics and individualize treatment of cancer and other diseases.

Additional Link:
Register to attend the Inventorship Showcase: http://www.lsu.edu/innovation/2018inventorshipshowcase/2018registration.php





Contact Alison Satake
LSU Media Relations