SPRING SEMINAR SERIES                       

Comparative Biomedical Sciences                  

School of Veterinary Medicine

Room 1212C - 12 Noon



February 8, 2018


Michael F. Salvatore, PhD

Associate Professor

Institute for Healthy Aging

Center for Neuroscience Discovery

University of North Texas Health Science Center


Host: Dr. Michael Mathis


 “Preserving dopamine biosynthesis in substantia nigra to maintain motor function: evidence from

rodent aging and Parkinson’s models”


The preservation of dopamine neurotransmission in the striatum has been long-presumed to be a therapeutic goal for preserving or restoring locomotor impairment in both aging and Parkinson’s disease.  However, evidence from many studies challenge this long-held dogma.  We will present evidence that protecting and preserving tyrosine hydroxylase expression and function in the substantia nigra, rather than striatum, will be critical for restoring or protecting against loss of motor function.   We will show evidence to support this hypothesis from established aging and Parkinson’s disease rodent models.  Furthermore, the is evidence that non-invasive approaches like exercise and calorie restriction prevent motor decline by increasing dopamine in the substantia nigra.  Our lab’s long-term goals are to encourage the inclusion of interrogation of dopamine function in the substantia nigra to further resolve the dire necessity to improve motor function in our aging population, including those with Parkinson’s disease.



Thanks to our Guest Speakers for Spring 2018


January 11, 2018

Thank you, Natalie M. Johnson!

Professor of Immunology & Microbiology
Department of Environmental & Occupational Health
Texas A&M University School of Public Health


January 25, 2018

Thank you, Ronald Klein!

Department of Pharmacology, Toxicology & Neuroscience
Louisiana State University Health Sciences Center-Shreveport