Bibliography of Publications Related to Deafness in Dogs

The National Library of Medicine's PubMed site is useful for locating research and medical publications and often provides an abstract of the article. This link will open in a new window.

This listing should be considered a work in progress. See also Bibliography of Publications Related to Deafness in Cats.

• Ahlström LA, Wilson WJ, Mills PC. 2005. Unilateral deafness in a white Bull Terrier diagnosed by BAER assessment. Australian Veterinary Journal 83:742-73.
• Anderson, H., Henricson, B., Lundquist, P.-G., Wedenberg, E. & Wersäll, J. 1968. Genetic hearing impairment in the Dalmatian dog. An audiometric, genetic and morphologic study in 53 dogs. Acta Oto-Laryngologica Suppl 23,1-34.
• Barry SJ, Barry SD. 1980. Surface-recorded auditory brainstem responses in the dog. Journal of Auditory Research 20:249-52.
• Becker, SC. 1998. Living With a Deaf Dog. Cincinnati, Susan Cope Becker.
• Beerman F, Orlow SJ & Lamoreux ML. 2004. The Tyr (albino) locus of the laboratory mouse. Mammalian Genome 15:749-758.
• Beurg M, Hafidi A, Skinner L, Cowan G, Hondarrague Y, Mitchell TJ, & Dulon D. The mechanism of pneumolysin-induced cochlear hair cel death in the rat. Journal of Physiology 568.1: 211-227.
• Bianchi E, Dondi M, & Poncelet L. 2006. N3 potentials in response to high intensity auditory stimuli in animals with suspected cochleo-saccular deafness. The Veterinary Journal (in press; available on line).
• Bodenhamer RD, Hunter JF, & Luttgen PJ. 1985. Brain stem auditory-evoked responses in the dog. American Journal of Veterinary Research 46:1787-1792.
• Bondurand N, Pingault V, Goerich DE, Lemort N, Sock E, Le Caignec C, Wegner M, & Goossens M. 2000. Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome. Human Molecular Genetics 9:1907-1917.
• Branis M, Burda H. 1985. Inner ear structure in the deaf and normally hearing Dalmatian dog. Journal of Comparative Pathology 95:295-299.
• Breen M, Jouquand S, Renier C, Mellersh CS, Hitte C, Holmes NG, Cheron A, Suter N, Vignaux F, Bristow AE, Priat C, McCann E, Andre C, Boundy S, Gitsham P, Thomas R, Bridge WL, Spriggs HF, Ryder EJ, Curson A, Sampson J, Ostrander EA, Binns MM, Galibert F. 2001. Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes. Genome Research 11:1784-1795.
• Brenig B, Pfeiffer I, Jaggy A, Kathmann I, Balzari M, Gaillard C, Dolf G. 2003. Analysis of the 5' region of the canine PAX3 gene and exclusion as a candidate for Dalmatian deafness. Animal Genetics 34:47-50.
• Brighton P, Ramesar R, & Winship I. 1991. Hearing impairment and pigmentary disturbance. Annals of the New York Academy of Science 630:152-166.
• Brooksbank S, MacMillan S, & Wymore SA/Dalmatian Club of America. 1997. The Official Book of the Dalmatian. TFH Publications, Neptune City, NJ.
• Brown KS, Bergsma DR, & Barrow MV. 1971. Animal models of pigment and hearing abnormalities in man. Birth Defects Original Article Series 7:102-109.
• Buchwald JS, Huang C. 1975. Far-field acoustic response: origins in the cat. Science 189:382-384.
• Burghes AHM, Vaessin HEF, & de la Chapelle A. 2001. The land between Mendelian and multifactorial inheritance. Science 293:2213-2214.
• Cargill, E.J., Famula, T.R., Strain, G.M. & Murphy K.E. 2001. Genetic analyses of hereditary deafness: a canine model. Fourth Conference on the Molecular Biology of Hearing and Deafness (NIDCD/DRF). Bethesda, MD, Oct. 2001, p. 115.
• Cargill EJ, Clark LA, Steiner JM, Murphy KE. 2002. Multiplexing of canine microsatellite markers for whole-genome screens. Genomics 80:250-3.
• Cargill EJ, Famula TR, Strain GM, Murphy KE. 2004. Heritability and segregation analysis of deafness in U.S. Dalmatians. Genetics 166:1385-1393.
• Cargill EJ, Famula TR, Schnabel RD, Strain GM, Murphy KE. 2005. The color of a Dalmatian's spots: linkage evidence to support the TYRP1 gene. BMC Veterinary Research 1:1-3.
• Cattanach, B. 1999. The "dalmatian dilemma": white coat colour and deafness. Journal of Small Animal Practice 40:193-200.
• Clark RD & Stainer JR. 1994. Medical and Genetic Aspects of Purebred Dogs. Fairway, Kansas Forum Publications.
• Clark LA, Wahl JM, Rees CA, & Murphy KE. 2006. Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog. Proceedings of the National Academy of Sciences, 103(5):1376-81.
• Cook LB. 2004. Neurologic evaluation of the ear. Veterinary Clinics of North America: Small Animal Practice 34:425-435.
• Coppens AG, Resibois A, & Poncelet L. 2000. Bilateral deafness in a Maltese terrier and a Great Pyrenean puppy: inner ear morphology. Journal of Comparative Pathology 122:223-228.
• Coppens AG, Resibois A, & Poncelet L. 2000. Immunolocalization of calbindin D28k and calretinin in the dog cochlea during postnatal development. Hearing Research 145:101-10.
• Coppens AG, Kiss R, Heizmann CW, Schafer BW, & Poncelet L. 2001. Immunolocalization of the calcium binding S100A1, S100A5 and S100A6 proteins in the dog cochlea during postnatal development. Brain Research Developmental Brain Reseach 28;126:191-9.
• Coppens AG, Kiss R, Heizmann CW, Deltenre P, & Poncelet L. 2001. An original inner ear neuroepithelial degeneration in a deaf Rottweiler puppy. Hearing Research 161:65-71.
• Coppens AG, Salmon I, Heizmann CW, Kiss R, & Poncelet L. 2003. Postnatal maturation of the dog stria vascularis - an immunohistochemical study. Anatomical Record Part A 270A:82-92.
• Coppens AG, Steinberg SA, & Poncelet L. 2003. Inner ear morphology in a bilaterally deaf Dogo Argentino pup. Journal of Comparative Pathology 128:67-70.
• Coppens AG, Salmon I, Heizmann CW, & Poncelet L. 2004. Dark-cell areas in the dog vestibular endorgans: an immunohistochemical study. Histology and Histopathology 19:1227-1235.
• Coppens AG, Gilbert-Gregory S, Steinberg SA, Heizmann C, & Poncelet L. 2005. Inner ear histopathology in "nervous Pointer dogs" with severe hearing loss. Hearing Research 200:51-62.
• Cordaux R & Batzer MA. 2006. Teaching an old dog new tricks: SINEs of canine genomic diversity. Proceedings of the National Academy of Sciences, 9 January 2006, 103(5):1157-8.
• Couturier L, Degueurce C, Ruel Y, Dennis R, & Begon D. 2005. Anatomical study of cranial nerve emergence and skull foramina in the dog using magnetic resonance imaging and computed tomography. Veterinary Radiology & Ultrasound 46:375-383.
• Defalque VE, Rosenstein DS, & Rosser EJ Jr. 2005. Measurement of the normal middle ear cavity volume in mesaticephalic dogs. Veterinary Radiology & Ultrasound 46:490-493
• Deol MS. 1970. The relationship between abnormalities of pigmentation and of the inner ear. Proceedings of the Royal Society of London 175:201-217.
• Dickie AM, Doust R, Cromarty L, Johnson VS, Sullivan M, & Boyd JS. 2003. Ultrasound imaging of the canine tympanic bulla. Research in Veterinary Science 75:121-126.
• Ding ZN, Yoshita Y, Hirota K, Yamamoto K, Kobayashi T, Murakami S. 1992. Brainstem auditory evoked potentials during procaine toxicity in dogs. Canadian Journal of Anaesthesia 39:600-3.
• Drögemüller C, Rak SG, Kuiper H, Leeb T, Quignon P, Galibert F, & Distl, O. 2002. Assignment of the canine tectorin alpha gene (TECTA) to CFA5q12q13 by FISH and confirmation by radiation hybrid mapping. Cytogenetic Genome Research 97:136-139.
• Eger CE & Lindsay P. 1997. Effects of otitis on hearing in dogs characterized by brainstem auditory evoked response testing. Journal of Small Animal Practice 38:380-386.
• Elkins, A.D., Hedlund, C.S., & Hobson, H.P. 1981. Surgical management of ossified ear canals in the canine. Veterinary Surgery 10, 163-168.
• Erickson, F., Saperstein, G., Leipold, H.W. & McKinley, J. 1977. Congenital defects of dogs. Part 1. Canine Practice 4, 54-61.
• Famula, T.R., Oberbauer, A.M. & Sousa, C.A. 1996. A threshold model analysis of deafness in Dalmatians. Mammalian Genome 7, 650-3.
• Famula TR, Oberbauer AM, Sousa CA. 2000. Complex segregation analysis of deafness in Dalmatians. American Journal of Veterinary Research 61:550-3.
• Famula, T.R., Oberbauer, A.M. & Williams, D.C. 2001. Gender effects in hearing loss in Dalmatians. Preventive Veterinary Medicine 48, 15-24.
• Ferrara ML, Halnan CR. 1983. Congenital structural brain defects in the deaf Dalmatian. Veterinary Record 112:344-346.
• Ferrara ML. 1986. Congenital Dalmatian deafness syndrome. Doctoral dissertation, University of Sydney, Sydney, Australia.
• Fischer A, Obermaier G. 1994. Brainstem auditory-evoked potentials and neuropathologic correlates in 26 dogs with brain tumors. Journal of Veterinary Internal Medicine 8:363-9.
• Foley CW. 1979. Abnormalities of Companion Animals. Analysis of Heritability. Ames IA:Iowa State University Press.
• Forsythe WB. 1985. Typanographic volume measurements of the canine ear. American Journal of Veterinary Research 46:1351-1353.
• Foss, I. 1981. Development of hearing and vision, and morphological examination of the inner ear in hereditarily deaf white Norwegian dunkerhounds and normal dogs (black and dappled Norwegian dunkerhounds). Masters thesis, Cornell University, Ithaca, NY. 133 pp.
• Gaillard, C., Yuzbasiyan-Gurkan, V., Nolan, E.R., Miyake, T., Jaggy, A. & Dolf, G. 2002. Segregation analyses of deafness in large pedigrees of Dalmatians. International Conference on Animal Genetics, Goettingen, Germany, August, 2002, Poster C-11.
• Giuffra E, Tornsten A, Marklund S, Bongcam-Rudolff E, Chardon P, Kijas JMH, Anderson SI, Archibald AL, & Andersson L. 2002. A large duplication associated with dominant white color in pigs originated byhomologous recombination between LINE elements flanking KIT. Mammalian Genome 13:569-577.
• Glazier AM, Nadeau JH, & Altman TJ. Finding genes that underlie complex traits. Science 298:2345-2349.
• Gregory SP. 2000. Middle ear disease associated with congenital palatine defects in seven dogs and one cat. Journal of Small Animal Practice 41:398-401.
• Greibrokk, T. 1994. Hereditary deafness in the Dalmatian: Relationship to eye and coat color. Journal of the American Animal Hospital Association 30:170-176.
• Guyon R, Lorentzen TD, Hitte C, Kim L, Cadieu E, Parker HG, Quignon P, Lowe JK, Renier C, Gelfenbeyn B, Vignaux F, DeFrance HB, Gloux S, Mahairas GG, Andre C, Galibert F, Ostrander EA. 2003. A 1-Mb resolution radiation hybrid map of the canine genome. Proceedings of the National Academy of Science 100:5296-5301.
• Harvey SJ, Mount R, Sado Y, Naito I, Ninomiya Y, Harrison R, Jefferson B, Jacobs R, Thorner PS. 2001. The inner ear of dogs with X-linked nephritis provides clues to the pathogenesis of hearing loss in X-linked Alport syndrome. American Journal of Pathology 159:1097-1104.
• Hayes, H.M., Wilson, G.P., Fenner, W.R. & Wyman, M. 1981. Canine congenital deafness: epidemiologic study of 272 cases. Journal of the American Animal Hospital Association 17:473-476.
• Hedan B, Corre S, Hitte C, Dreano S, Vilboux T, Derrien T, Denis B, Galibert F, Galibert MD, Andre C. 2006. Coat colour in dogs: identification of the Merle locus in the Australian shepherd breed. BMC Veterinary Research 2:1-10.
• Heffner HE. 1983. Hearing in large and small dogs: Absolute thresholds and size of the tympanic membrane. Behavioral Neuroscience 97:310-318.
• Henthorn PS, Gilbert-Gregory S, Hong T, Petra W, Steinberg S. 2006. Probable mutation associated with non-syndromic deafness in pointer dogs. Third International Conference on Advances in Canine and Feline Genomics, Davis, CA, Aug, 2006. To be published in a future issue of the Journal of Heredity.
• Hewson-Fruend, H.J. 1990. Deafness in the Australian Cattle Dog. A proposed mode of inheritance. Australian Cattle Dog Society of Great Britain Newsletter Autumn 1990, 7-10.
• Hiraide F & Paparella MM. 1988. Histopathology of the temporal bones of deaf dogs. Auris Nasus Larynx (Tokyo) 15:97-104
• Holliday TA & Te Selle ME. 1985. Brain stem auditory-evoked potentials of dogs: wave forms and effects of recording electrode positions. American Journal of Veterinary Research 46:845-851.
• Holliday, T.A., Nelson, H.J., Williams, D.C. & Willits, N. 1992. Unilateral and bilateral brainstem auditory-evoked response abnormalities in 900 Dalmatian dogs. Journal of Veterinary Internal Medicine 6, 166-174.
• Hood JC, Huxtable C, Naito I, Smith C, Sinclair R, Savige J. 2002. A novel model of autosomal dominant Alport syndrome in Dalmatian dogs. Nephrology, Dialysis and Transplantation 17:2094-8.
• Huang C-M. 1980. A comparative study of the brain stem auditory response in mammals. Brain Research 184:215-219.
• Hudson, W.R. & Ruben, R.J. 1962. Hereditary deafness in the Dalmatian dog. Archives of Otolaryngology 75, 213-219.
• Igarashi, M., Alford, B.R., Cohn, A.M., Saito, R., & Watanabe, T. 1972. Inner ear abnormalities in dogs. Annals of Otology, Rhinology, and Laryngology 81, 249-255.
• Johnsson, L.G., Hawkins, J.E. Jr., Muraski, A.A. & Preston, R.E. 1973. Vascular anatomy and pathology of the cochlea in Dalmatian dogs. In: Vascular Disorders and Hearing Defects, ed. A.J.D. de Lorenzo. pp 249-295. Baltimore: University Park Press.
• Johnston, D.E. & Cox, B. 1970. The incidence in purebred dogs in Australia of abnormalities that may be inherited. Australian Veterinary Journal 46., 465-474.
• Jones TA & Weidner WJ. 1986. Effects of temperature and elevated intracranial pressure on peripheral and brain stem auditory responses in dogs. Experimental Neurology 92:1-12.
• Juraschko K. 2000. Populationsgenetische Untersuchung der kongenitalen Taubheit beim Dalmatiner (Genetic analysis of congenital deafness in Dalmatians). Doctoral thesis, Tierarztliche Hochschule Hannover, Hanover, Germany.
• Juraschko K, Meyer-Lindenberg A, Nolte I, & Distl, O. 2003. Analysis of systematic effects on congenital sensorineural deafness in German Dalmatian dogs. Veterinary Journal 166:164-169.
• Juraschko K, Meyer-Lindenberg A, Nolte I, & Distl, O. 2003. A regressive model analysis of congenital sensorineural deafness in German Dalmatian dogs. Mammalian Genome 14:547-554.
• Kawasaki Y, Inada S. 1992. Effects of analog filtering on brain stem auditory-evoked potentials in dogs. American Journal of Veterinary Research 53:1096-1100.
• Kawasaki Y, Inada S. 1993. Power spectral analysis and digital filtration of brain stem auditory evoked potentials in dogs. American Journal of Veterinary Research 54:1822-6.
• Kawasaki Y, India S. 1994. Peaks of brainstem auditory evoked potentials in dogs. Veterinary Research Communications 18:383-396.
• Karlsson EK, Hillbertz NS, Wade CM, Andersson G, von Euler H, Hedhammar Å, Zody MC, Biagi T, Lai J, Anderson N, Liu G, Jones K, Andersson L, Lindblad-Toh K. 2006. Two-stage association mapping in dogs identifies coat color locus. Third International Conference on Advances in Canine and Feline Genomics, Davis, CA, Aug, 2006. To be published in a future issue of the Journal of Heredity.
• Kay R, Palmer AC, & Taylor PM. 1984. Hearing in the dog as assessed by auditory brainstem evoked potentials. The Veterinary Record 114:81-84.
• Kerns JA, Newton J, Berryere TG, Rubin EM, Cheng J-F, Schmutz SM & Barsh GS. 2004. Characterization of the dog Agouti gene and a nonagouti mutation in German Shepherd Dogs. Mammalian Genome 15:798-808.
• Kerns JA, Cargill EJ, Clark LA, Candille SI, Berryere T, Oliver M, Lus G, Schmutz SM, Murphy KE, & Barsh GS. 2007. Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics 176:1679-1689.
• Kim JS, Lopez I, DiPatre PL, Liu F, Ishiyama A, & Baloh RW. 1999. Internal auditory artery infarction. Clinicopathologic correlation. Neurology 52(1): 40-44.
• Kirkness EF, Bafna V, Halpern AL, Levy S, Remington K, Rusch DB, Delcher AL, Pop M, Wang W, Fraser CM, & Venter JC. 2003. The dog genome: survey sequencing and comparative analysis. Science 301:1898-1903.
• Kneissl S, Probst A, & Konar M. 2004. Low-field magnetic resonance imaging of the canine middle and inner ear. Veterinary Radiology & Ultrasound 45:520-522.
• Knowles, K., Cash, C.W., & Blauch, B.S. 1988. Auditory-evoked responses of dogs with different hearing abilities. Canadian Journal of Veterinary Research 52, 394-397.
• Knowles, K., Blauch, B., Leipold, H., Cash, W., & Hewett, J. 1989. Reduction of spiral ganglion neurons in the aging canine with hearing loss. Journal of Veterinary Medicine A 36, 188- 199.
• Koterbay AM. 1999. Congenital hereditary deafness in Jack Russell terriers. Histological observations of cochlear degeneration and the superficial structural changes of the auditory cortex. Masters thesis, Auburn University, Auburn, Alabama.
• Krahwinkel, D.J., Pardo, A.D., Sims, M.H., & Bubb, W.J. 1993. Effect of total ablation of the external acoustic meatus and bulla osteotomy on auditory function in dogs. Journal of the American Veterinary Medical Association 202: 949-952.
• Krempler A, Breen M, Brenig B. 2000. Assignment of the canine paired-box 3 (PAX3) gene to chromosome 37q16-->q17 by in situ hybridization. Cytogenetics and Cell Genetics 90:66-7.
• Kuiper H, Rak SG, Drogemuller C, Leeb T, Quignon P, Galibert F, Distl O. 2002. Assignment of the canine cadherin related 23 gene (CDH23) to chromosome 4q12-->q13 by fluorescence in situ hybridization and radiation hybrid mapping. Cytogenetic and Genome Research 97:140B.
• Kuse H, Okaniwa A. 1993. Postnatal development of the auditory brainstem response (ABR) in beagles. Jikken Dobutsu 3:377-382.
• Lee H, Baloh RW. 2005. Sudden deafness in vertebrobasilar ischemia: clinical features, vascular topographical patterns and long-term outcome. Journal of the Neurological Sciences 228:99-104.
• Lindblad-Toh K, Wade CM, Mikkelsen TS, et al (46 authors). 2005. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438(8):803-819.
• Little, C.C. 1957. The Inheritance of Coat Color in Dogs. New York: Howell.
• Lou X-Y, Todhunter RJ, Lin M, Lu Q, Liu T, Wang Z, Bliss SP, Casella G, Acland GM, Lust G, & Wu R. 2003. The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigree. Mammalian Genome 14:555-564.
• Lurie MH. 1948. The membranous labyrinth in the congenitally deaf collie and Dalmatian dog. Laryngoscope 58, 279-287.
• Mair IWS. 1976. Hereditary deafness in the Dalmatian dog. Archives of Otorhinolaryngology 212, 1-14.
• Mair IWS. 1979. Diseases of the ear. In: Andrews EJ, Ward BC, Altman NH, eds. Spontaneous Animal Models of Human Disease. Academic Press,3:83-94.
• Mansfield, P.D. 1990. Ototoxicity in dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian 12, 331-337.
• Markessis E, Poncelet L, Colin C, Coppens A, Hoonhorst I, Deggouj N, & Deltenre P. 2006. Auditory steady-state evoked potentials (ASSEPs): A study of optimal stimulation parameters for frequency-specific threshold measurement in dogs. Clinical Neurophysiology 117:1760-1771.
• Marshall AE. 1985. Brain stem auditory-evoked response of the nonanesthetized dog. American Journal of Veterinary Research 46:966-973.
• Matsushima Y, Shinkai Y, Kobayashi Y, Sakamoto M, Kunieda T, & Tachibana M. 2002. A mouse model of Waardenburg syndrome type 4 with a new spontaneous mutation of the endothelin-B receptor gene. Mammalian Genome 13:30-35.
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• McAnulty JF, Hattel A, Harvey CE. 1995. Wound healing and brain stem auditory evoked potentials after experimental ventral tympanic bulla osteotomy in dogs. Veterinary Surgery 24:9-14.
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• Munro KJ, Shiu JN & Cox CL. 1997. The effect of head size on the auditory brainstem response for two breeds of dog. British Journal of Audiology 31:309-314.
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• Poncelet L, Coppens A, & Deltenre PF. 2000. Brainstem auditory evoked potential wave V latency-intensity function in normal Dalmatian and Beagle puppies. Journal of Veterinary Internal Medicine 14:424-428.
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• Rak SG & Distl O. 2005. Congenital sensorineural deafness in dogs: A molecular genetic approach toward unravelling the responsible genes. The Veterinary Journal 169:188-196.
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• Richman M, Mellersh CS, André C, Galibert F, Ostrander EA. 2001. Characterization of a minimal screening set of 172 microsatellite markers for genome-wide screens of the canine genome. Journal of Biochemical and Biophysical Methods 47:137-49.
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Online Mendelian Inheritance in Man (OMIM) References:

• 600965 http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600965
• 220290 http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=220290
• 607841 http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607841
• 601071 http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601071

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